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Keywords DNA adducts;binding site;high throughput; DNA加合物;结合位点;高通量;
Keywords DNA adduct;Biomarker;Qiantang river;Carcinogen; DNA加合物;生物标志物;钱塘江;致癌物;
Oxidative base damages are primarily removed by BER 65, whereas DNA adducts are repaired mostly by NER64. 氧化基的损失主要是去除误码率，而DNA加合物的修复主要通过NER。
With the deepening research on etiology mechanism of tumour, people pay more and more attention to DNA adducts. 随着人们对肿瘤发病机制认识水平的不断深入,DNA加合物的研究也越来越受到重视。
The result showed that 1,4-benzoquinone and ct-DNA did interact and formed DNA adducts. 研究发现,苯醌对小牛胸腺DNA能产生相互作用并形成DNA加合物,获得了苯醌对小牛胸腺DNA有损伤作用的判断。
With the cognitive penetration of ecotoxicological effects into a molecular level,more attention has been paid to the research on DNA adducts. 随着人们对污染生态毒理效应认识水平的不断深入;DNA加合物的研究日益受到重视.;本文首先对DNA加合物的毒性机理与DNA加合物形成过程进行了分析;
The pollution-exposure indication of DNA adducts was expounded as an effective molecular biomarker,and thus,DNA adducts could be u... 最后对DNA加合物的污染暴露指示进行了论述;指出DNA加合物作为有效的分子生物标记物是生态毒理学家用来预测污染物危害效应的警示信号.
In addition, a good linear correlation between the liver/lung/kidney DNA adducts level with Hb (hemoglobin) adducts level was observed. 另外，肝/肺/肾DNA加合物的水平和血红蛋白（Hb）加合物的水平也有很好的线性响应关系，说明MTBE-Hb加合物可以取代MTBE-DNA加合物用作MTBE暴露的生物标志物（biomarker）。
DNA adducts is a very important class of biomarkers of human exposure to carcinogen, cancer risk assessment, and population susceptibility. 摘要 DNA加合物是一类重要的生物标志物,可应用于人体致癌物暴露监测、癌症风险评价和人群易感性研究。
The reliable, sensitive and accurate detection and identification of DNA adducts is a key to the wide application of DNA adducts as biomarkers. 可靠、灵敏、准确的分析检测技术是DNA加合物作为生物标志物得到广泛应用的关键。
There is a lack of a technology with a sufficient sensitivity to detect trace DNA adducts related to low environmental exposure levels. DNA加合物作为生物标志物的应用需要安全、灵敏、快速的先进分析技术。
Methods:DNA adducts in gill of wild crucian from Wenjiayan,Lan River and Qu River in Qiantang valley were detected and compared with those from Chunan Qiandao lake(control). 方法:以淳安千岛湖作为对照点,以钱塘江水系中闻家堰、兰江和衢江段为调查区,对各个采样点野生鲫鱼鳃DNA加合物水平进行测定。
DNA adduct level was related to the histological classification, degree of cell differentiation ... 肺癌组织加合物含量与组织学类型、细胞分化程度和淋巴结转移状态均有密切关系。
Keywords Styrene;DNA adduct;Chemical damage; 苯乙烯;DNA加合物;化学损伤;
The DNA adduct formation and cytochrome P450 1A1 (CYP1A1) induction have been suggested to be the major determinant of their carcinogenic activity. 已知多环芳香烃对细胞色素P450 1A1 (CYP1A1) 之诱发能力和形成DNA键结物以及引起肿瘤形成呈正相关性。
Keywords Nucleotides;Lung neoplasms;DNA adducts;Gene;ERCC1; 关键词核苷酸类;肺肿瘤;DNA加合物;基因;ERCC1;
Objective and Methods: To study the normal level of DNA adducts and its influential factors, DNA adducts in peripheral lymphocytes of 246 inhabitants was detected by bioluminescence. 目的与方法:为了研究人群DNA加合物的正常水平及其影响因素,本文利用化学发光法测定了246例正常外周淋巴细胞DNA加合物水平,并分析了抽烟、饮食习惯等生活方式对DNA加合物水平的影响。
A number of techniques and methods have been developed for the detection of DNA adducts, such as 32P-postlabelling, immunoassay, immuno-CE/LIF, LC/MS, micro-scale separation coupled MS. 当前DNA加合物分析、检测的方法主要包括：32P后标记法、免疫分析法、免疫毛细管电泳激光诱导荧光法、液相色谱串联质谱法、微分离-质谱联用法等。
Keywords DNA;atebrine;fluorescence quenching; 阿的平;荧光猝灭;
Keywords DNA;porphyrin;methylene blue;interaction; 卟啉;亚甲基兰;相互作用;